Publications

• The role of inflammation in the immune evasion of KRas Homan EJ, Bremel RD. Front Immunol. 2026 May 7;17:1831303. doi: 10.3389/fimmu.2026.1831303. eCollection 2026. PMID: 42183221

• Determinants of tumor immune evasion: the role of T cell exposed motif frequency and mutant amino acid exposure. Homan EJ, Bremel RD. Front Immunol. 2023 May 5;14:1155679. doi: 10.3389/fimmu.2023.1155679. eCollection 2023. PMID: 37215122

• Endoglucanase 2 (Eng2), a shared immunodominant antigen in dimorphic fungi that elicits immunity during infection. Okaa UJ, Ledesma Taira C, Dos Santos Dias L, Dobson H, Kujoth GC, Campuzano A, Homan EJ, Thompson GR, Hung CY, Deepe GS Jr, Wüthrich M, Klein BS. J Clin Invest. 2025 Sep 25;135(22):e191103. doi: 10.1172/JCI191103. PMID: 41061037

• Catalytically Active Recombinant Cysteine Proteases of Haemonchus contortus: Their Ability to Degrade Host Blood Proteins and Modulate Coagulation. Karunakaran AC, Bakshi M, Rajendrakumar AM, Wilson-Welder JH, Aroian RV, Schwarz EM, Homan EJ, et al Int J Mol Sci. 2025 Dec 16;26(24):12077. doi: 10.3390/ijms262412077. PMID: 41465503

• Recombinant Bacillus Calmette-Guérin Expressing SARS-CoV-2 Chimeric Protein Protects K18-hACE2 Mice against Viral Challenge. Mambelli F, Marinho FV, Andrade JM, de Araujo ACVSC, Abuna RPF, Fabri VMR, Santos BPO, da Silva JS, de Magalhães MTQ, Homan EJ, Leite LCC, Dias GBM, Heck N, Mendes DAGB, Mansur DS, Báfica A, Oliveira SC. J Immunol. 2023 Jun 15;210(12):1925-1937. doi: 10.4049/jimmunol.2200731. PMID: 37098890

• CD4+ T Cells in the Blood of MS Patients Respond to Predicted Epitopes From B cell Receptors Found in Spinal Fluid. Høglund RA, Bremel RD, Homan EJ, Torsetnes SB, Lossius A, Holmøy T. Front Immunol. 2020 Apr 9;11:598. doi: 10.3389/fimmu.2020.00598. eCollection 2020. PMID: 32328067.

• Human Cysteine Cathepsins Degrade Immunoglobulin G In Vitro in a Predictable Manner. Høglund RA, Torsetnes SB, Lossius A, Bogen B, Homan EJ, Bremel R, Holmøy T. Int J Mol Sci. 2019 Sep 29;20(19):4843. doi: 10.3390/ijms20194843. PMID: 31569504.

• Immunoinformatic Analysis of SARS-CoV-2 Nucleocapsid Protein and Identification of COVID-19 Vaccine Targets. Oliveira SC, de Magalhães MTQ, Homan EJ. Front Immunol. 2020 Oct 28;11:587615. doi: 10.3389/fimmu.2020.587615 PMID: 33193414

• Immunoglobulin somatic hypermutation has clinical impact in DLBCL and potential implications for immune checkpoint blockade and neoantigen-based immunotherapies. Xu-Monette ZY, Li J, Xia Y, Crossley B, Bremel RD, et al. J Immunother Cancer. 2019 Oct 22;7(1):272. doi: 10.1186/s40425-019-0730-x. PMID: 31640780

• Schistosoma mansoni Sm KI-1 or Its C-Terminal Fragment Induces Partial Protection Against S. mansoni Infection in Mice Morais SB, Figueiredo BC, Assis NRG, Homan J, Mambelli FS, Bicalho RM, Souza C, Martins VP, Pinheiro CS and Oliveira SC (2018). Front. Immunol. 9:1762. doi: 10.3389/fimmu.2018.01762. PMID 30105029

• A Role for Epitope Networking in ImmunomodulationHelminths. Homan EJ and Bremel RD (2018) Front. Immunol. 9:1763. doi: 10.3389/fimmu.2018.01763 PMID 30108588

• Vaccination with Recombinant Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species. Specht CA, Lee CK, Huang H, Hester MM, Liu J, Luckie BA, Torres Santana MA, Mirza Z, Khoshkenar P, Abraham A, Shen ZT, Lodge JK, Akalin A, Homan J, Ostroff GR, Levitz SM. MBio. 2017 Nov 28;8(6). pii: e01872-17. doi: 10.1128/mBio.01872-17. PMID:29184017

• In Silico Prediction Analysis of Idiotope-Driven T-B Cell Collaboration in Multiple Sclerosis. Høglund RA, Lossius A, Johansen JN, Homan J, Benth JŠ, Robins H, Bogen B, Bremel RD, Holmøy T. Front Immunol. 2017 Oct 2;8:1255. doi: 10.3389/fimmu.2017.01255. PMID:29038659

• Extensive T-Cell Epitope Repertoire Sharing among Human Proteome, Gastrointestinal Microbiome, and Pathogenic Bacteria: Implications for the Definition of Self. Bremel RD, Homan EJ. Front Immunol. 2015 Oct 22;6:538. doi: 10.3389/fimmu.2015.00538. eCollection 2015. PMID: 26557118

• Frequency Patterns of T-Cell Exposed Amino Acid Motifs in Immunoglobulin Heavy Chain Peptides Presented by MHCs. Bremel RD, Homan EJ. Front Immunol. 2014 Oct 28;5:541. doi: 10.3389/fimmu.2014.00541. eCollection 2014. Review. PMID: 25389426

• Are cases of mumps in vaccinated patients attributable to mismatches in both vaccine T-cell and B-cell epitopes?: An immunoinformatic Homan EJ, Bremel RD. Hum Vaccin Immunother. 2014;10(2):290-300. doi: 10.4161/hv.27139. Epub 2013 Nov 25. PMID:24275080

• Recognition of higher order patterns in proteins: immunologic kernels. Bremel RD, Homan EJ. PLoS One. 2013 Jul 29;8(7):e70115. doi: 10.1371/journal.pone.0070115. Print 2013. PMID: 23922927

• Patterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutinin. Homan EJ, Bremel RD. PLoS One. 2011;6(10):e26711. doi: 10.1371/journal.pone.0026711. Epub 2011 Oct 24. PMID: 22039539

• An integrated approach to epitope analysis II: A system for proteomic-scale prediction of immunological characteristics. Bremel RD, Homan EJ. Immunome Res. 2010 Nov 2;6:8. doi: 10.1186/1745-7580-6-8. PMID: 21044290

• An integrated approach to epitope analysis I: Dimensional reduction, visualization and prediction of MHC binding using amino acid principal components and regression approaches. Bremel RD, Homan EJ. Immunome Res. 2010 Nov 2;6:7. doi: 10.1186/1745-7580-6-7. PMID: 21044289