Mapping the Immunome

The adaptive immune response involves three types of signal processing: those which are largely stochastic, those which are innate and essentially common to all individuals, and those which are dependent on the genetics of the host. Modeling of the immune response requires understanding that there is a vast diversity of inputs, whether from many different and diverse microorganisms or environmental stimuli, or isotypes of endogenous proteins. The hosts – human or animal populations – which respond are also highly diverse in their immunogenetics. The diversity of the host immunogenetics has a far reaching impact on the immune response and plays a determinant role in the outcome of infectious disease, autoimmunity, cancer, biotherapeutic proteins, vaccines, and even many small molecule drug therapies in any one patient.

Thus modeling immune recognition requires understanding that it occurs at the interface of two sources of diversity – host and immunogen – and is modulated by stochastic, innate, and genetically determined processes. These each provide checks and balances and it is the interaction of multiple signals and responses which determines the overall response. With uTOPE™ analysis we integrate the complex pattern of interactions.